OVERVIEW

Anti-idiotype antibodies specifically bind to the unique idiotope located in the variable region of the target antibody. During drug development, they can be used to selectively identify therapeutic antibodies in vivo and distinguish them from endogenous antibodies naturally present in serum and other samples, making them essential reagents for pharmacokinetic (PK) studies. In addition, due to their similarity to anti-drug antibodies (ADA), anti-idiotype antibodies also serve as important references in immunogenicity assessments.

• 

  Competitive Type

  Competes with antigen for binding

  Complementarity-determining region (CDR) specificity

  Detects free-form antibody drugs

• 

  Non-competitive Type

  Do not compete with antigen for binding

  Non-CDR specificity

  Detects total antibody drug

• 

  Complex Type

  Do not compete with antigen for binding

  Specific to antigen-antibody complex

  Detects bound-form antibody drugs

WHAT WE CAN PROVIDE

• 01Mouse anti-idiotype monoclonal antibodies
• 04Immunogenicity analysis
• 02Rabbit anti-idiotype monoclonal antibodies
• 05Rabbit anti-idiotype polyclonal antibodies
• 03Detection Kits Development
• 06Detection Kits Development