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- GU-Flash Recombinant Antibody Expression
OVERVIEW
Gene Universal’s GU-Flash system is a cutting-edge transient expression platform designed for monoclonal antibodies (mAbs), bispecific antibodies, and VHH antibodies. With multiple options—GU-Flash (CHO-s), GU-FlashK1 (CHO-K1), GU-FlashSA (sialylated), and GU-FlashAFuco (afucosylated)—we deliver gram-level expression, improved stability, and reduced aggregation, accelerating your biopharmaceutical development from discovery to preclinical research.
OUR ADVANTAGES
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Rapid, Predictable Timelines
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High, Scalable Yields
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Flexible CHO Platforms & Glycoengineering
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Broad Antibody Format Compatibility
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Optimized Quality & Stability
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Integrated Technical Support
OUR SERVICES
| Expression Type | System | Service Volume | Testing | Additional Services |
|---|---|---|---|---|
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Monoclonal Antibody (mAb) Bispecific Antibody Polyclonal Antibody Antibody Fragment Recombinant Protein |
GU-Flash (CHO-s) GU-FlashSA (Sialylation Enhanced) GU-FlashK1 (CHO-K1) GU-FlashAFuco (Afucosylated) |
1 ml 2 ml 10 ml 30 ml Scalable up to 100 L |
SDS-PAGE SEC-HPLC Endotoxin Level CE-SDS (Optional) Mass Spectrometry (Optional) |
BLI SPR FACS Antibody Screening Humanization / Affinity Maturation |
GENERAL WORKFLOW
From Gene Synthesis to Delivery as Fast as 1 weeks
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Antibody
Sequence -
Gene Synthesis
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Plasmid Prep
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Transient Transfection
& Expression -
Purification & QC
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Fast
Delivery
SERVICE DETAILS
| Service Step | Service Description | Lead time | Deliverable |
|---|---|---|---|
| Gene synthesis and cloning |
· Codon optimization and gene synthesis · Subcloning into an expression vector · Plasmid amplification and preparation |
1 week |
· Expression plasmid contain GOI
· Purified antibody (SEC-HPLC>95%, SDS-PAGE>95%, · COA Report |
| Transient expression & purification |
· Transfection of mammalian cells(CHO/293) · Transient expression and purification |
1 week |
SERVICE PACKAGES
Gene Universal offers 50% discount for a limited time with promo code "GU-Flash" when requesting a quote.Valid for orders placed between April 1st, 2026 and Jun 30th, 2026.
| Antibody Isotypes | Amount |
Leadtime (Standard Package) |
Leadtime (Fast Package) |
|---|---|---|---|
|
Mouse IgG1/IgG2a Human IgG1/IgG4 Rabbit IgG Fab/SCFV/VHH (His tag) |
0.2 mg-1 mg | 14 days | 7 days |
| >1mg | Inquiry | Inquiry |
Target Types: Recombinant proteins;Antibody formats including full length antibody, Fabs, scFvs, VHHs, or other fragments fused with Fc
CASE STUDY
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Figure 1. GU-Flash Transfection System: Yield and Purity Across Product Types
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Figure 2. Case Study of Sialylation Enhancement by GU-FlashSA (Left: CHO-s; Right: GU-FlashSA)
GU-FlashSA boosts antibody sialylation, safeguarding stability, reducing degradation, and enhancing half-life and receptor interaction
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Figure 3. GU-FlashAFuco Enhances Antibody ADCC by Reducing Fucosylation (Left: CHO-s; Right: GU-FlashAFuco)
Modification Fucosylated% (CHO-s) Fucosylated%(GU-FlashAFuco) N301+A2G0F 67.95 n/a N301+A2G1F 13.59 n/a N301+A1G0F 8.09 n/a N301+M5 5.27 0.73 N301+A2G0 3.22 81.9 N301+Unglycosylated 1.53 1.11 N301+A1G0 1.14 9.58 GU-FlashAFuco: Reducing Fucosylation to Boost ADCC((antibody-dependent cellular cytotoxicity)) Activity and Therapeutic Potency
Request A Quote
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